Been looking into this as well. New wheels can be tricky. Besides the already mentioned weight of each wheel, you also have total diameter to look at. Many times, when going up a wheel size, you come down a tire size (-1) to the total combined diameter stays the same. Which reduces the sidewall thickness and can lead to more tire blowouts and rim damage.
There is also the issue of the sound deadening in the tires as others have mentioned.
However the biggest surprise to me has been the fact that wheels are rated to the weight of the car. Many times, after market wheels are not designed to handle the extra weight of electric cars and this needs to be looked into when trying to purchase larger wheels.
So basically, you need a wheel/tire combo that is as light as factory, has the overall same rolling resistance/diameter, and is rated for the weight of your car.
What I have done on my previous electric cars is keep the larger wheel for summer driving and get a smaller rim with winter tires for colder driving. I try and recoup some of the lost range in the winter with smaller rims.
Does anyone know if the eTron will detect the change in rims and allow you to reset the system to accomodate? My current vehicle (Tesla S) detects the change in wheels and asks you which rim size is on the car now.