Just did this trip from South Bay to North Tahoe (Truckee area) with the '21 e-tron. Went way smoother than expected! Left the Bay area with ~100% charge, arrived at Rocklin EA charger with about 40% left. Charged at Rocklin to >90% while grabbing lunch at the nearby Panera. The range meter showed ~160 mi range with my destination at Donner Lake. It's really great that the range estimate seems to take elevation into account with the destination set! Arrived at my destination with ~50% of the battery remaining.
Overall, the experience was excellent. I daily drove an e-Golf for 2 years before switching to the e-tron, and I of course never made an attempt to go beyond the Bay Area with that car. The 200+ mile range, along with the 150 kW charging, has completely changed my expectation of what I can do with my EV!